For centuries, farmers gradually improved their crops. Today, modern agricultural biotechnology allows us to improve them in more targeted ways, and give plant varieties desirable characteristics, such as resistance to certain pests or herbicides, enhanced robustness against diseases, drought or water tolerance, or healthier profiles that can enhance nutrition.
Jeroen Hofenk, Chief Science Officer
Perpetuum is an agricultural biotech company developing safe and sustainable solutions for the effective management and improvement of agricultural crops. Perpetuum’s technologies aim to help increase global food production with products derived from natural biological sources.
Perpetuum’s vision is to apply the company’s expertise in plant biotechnology to provide global leadership in research, development and commercialisation of our technologies for crop improvement. This will contribute to sustainable industry practices and to safer, healthier, more plentiful food and a cleaner environment.
In early 2019, the multi-disciplinairy team at Perpetuum began to map out a scientific strategy, collaborations and operational plan. Each member brought a unique perspective and skill set to the internal collaboration. Many other colleagues and partners; from business development to human resources to legal to finance — also contributed time and perspective, highlighting the focus on cross-functional partnership that is a hallmark of Perpetuum's culture.
With rising demand for crop improvement, Perpetuum is in a position to secure very substantial value from its technology development in the > USD 67 billion global agricultural biotech market.
RECOMBINANT BIOINSECTICIDE R&D PIPELINE
Insect pests can reduce global crop yields by 10-14% annually and damage 9-20% of stored food crops. Several of these pest species are resistant to available insecticides. Many venomous animals have evolved to kill invertebrate prey, so it is logical to consider their venoms as potential bio-insecticides.
Venoms are a complex mixture of peptides, small molecules and proteins that affect molecular targets such as ion channels, GPCRs and kinases, often with exquisite potency and selectivity. They have been developed through millions of years of evolution, rather than a few hundred years of scientific study.
Chemical insecticides usually act on a small number of molecular targets (e.g. nAChR channels, GABA-gated Cl-channel, Glutamate-gated Cl-channel [GluCls]) and are therefore highly selective for insect pests. As a result, hundreds of species of insects have developed resistance to one or more classes of these insecticides. This development of insecticide resistance and concerns about environmental and human safety has resulted in a demand for new, environmentally sustainable bio-insecticides, using active ingredients with novel modes of action.
In contrast, venoms have a broad spectrum of insect-killing, and immobilising abilities that have evolved to avoid the development of resistance. Thus, isolated peptides from the venom of spiders or other venomous insectivorous animals, such as centipedes and scorpions, have the potential to serve as bio-insecticides.
Though chemical peptide synthesis is not economically viable to produce these toxins on an industrial scale, through our Transexpress Platform we offer a number of unique approach to development of recombinant venomous bio-insecticides.
WORK WITH US
We are dedicated to identifying partners who share our vision for the future of agricultural biotech. Our corporate development team works closely with our research, development and commercial groups to carefully identify and evaluate prospective opportunities that are strategically aligned with our objectives.
Our aim is to become the partner of choice for innovation in agricultural biotech. This is at the heart of how we approach partnerships and collaborations. At Perpetuum, innovation extends beyond our excisting programs to partnerships in which we engage. We look forward to learning more about your opportunity and discussing how we can partner with you.
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