TRANSEXPRESS PLATFORM

turning plants into mini-biofactories

 

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RECOMBINANT DNA TECHNOLOGY

What the public needs to understand is that recombinant DNA technology allows scientists to bypass biological boundaries altogether.

 

Uzzo Calderaro, Chief Business Development Officer

TURNING PLANTS INTO MINI-BIOFACTORIES

Plants are highly efficient at producing proteins of varying complexity, serving as bioreactors - or mini factories - for protein-based therapeutics. Perpetuum's plant-based production platform demonstrates better agility, accuracy, and speed compared with other manufacturing technologies by eliminating the risk of pathogens and contamination during production, and significantly shortening production timelines. 

 

Our platform scaleability is quite simple;  one plant or 10,000 plants require the same growth conditions whereas the capacity is adjustable to market needs.

HOW IT WORKS

SYNTHETIC GENE CLONING

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target gene is cloned into expression vector

1-2 days

 

GENE INTRODUCTION + GROW AGROBACTERIUM

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expression vector is introduced in agrobacterium

3-4 days

 

NATURAL SYNTHESIS OF PROTEIN

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DNA transcript is amplified in plant

5-6 days

 

PLANT INFILTRATION WITH AGROBACTERIUM

gene introduction by vacuum infiltration

1 day

 

BIOMASS PROCESSING + PROTEIN EXTRACTION

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leaves are grinded and protein is extracted

1 day

 

ISOLATION AND PURIFICATION

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sequential chromatography steps

1 day

 

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PROTEIN ANALYSIS

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sequential chromatography steps

1 day

 

KEY ADVANTAGES

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Rapid drug development

and production timelines

High levels of protein

expression

 

Mammalian-type glycosylation

(less risk of immune reactions)

 

 

Unlimited scale-up capability

(respond to increased demand)

 

Reduced risk profile

versatility

 

 

Manufacturing cost decreased

by as much as 90%

 

 

 

OUR OTHER TECHNOLOGIES

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GENOMIC

INSIGHTS

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CELL & TISSUE

DESIGN

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BABYBOOM

CLONING

 

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GENOMIC

BREEDING

 

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PRECISION

BREEDING

 

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